What disease does the anticoagulation test detect?

Anticoagulation test generally refers to the four coagulation tests, which is a common test item in the laboratory department. It belongs to the thrombotic disease test item. Especially before surgery, this kind of test must be carried out. Only by doing a good job of this kind of test can we avoid risks during the operation and avoid heavy bleeding during the operation. Hemostasis is very important.

Purpose of inspection

Before a patient is hospitalized for surgery, the doctor will always ask the patient to draw blood for four coagulation tests. The purpose is to understand whether the patient's hemostasis function is defective before the operation, so as to be prepared in advance and avoid being caught off guard by massive bleeding during the operation.

The body's hemostatic function is very important. When a person is accidentally injured and bleeding, the hemostatic function takes effect quickly, causing the blood to coagulate and block the wound to stop bleeding, thus avoiding massive blood loss. When a patient needs surgery, the physician must first understand the patient's hemostatic function. If the hemostatic function is not sound, the patient may bleed heavily during the operation, leading to surgical accidents or even death.

Various meanings

APTT: Mainly reflects the status of the endogenous coagulation system and is often used to monitor heparin dosage. Increased levels are seen in cases where plasma factor VIII, factor IX, and factor XI levels are reduced, such as in hemophilia A, hemophilia B, and factor XI deficiency; decreased levels are seen in cases where hypercoagulable states occur, such as when procoagulant substances enter the blood and the activity of coagulation factors increases.

PT: Mainly reflects the status of the extrinsic coagulation system, among which INR is often used to monitor oral anticoagulants. Prolongation is seen in congenital coagulation factor IIⅤⅦⅩ deficiency and fibrinogen deficiency. Acquired coagulation factor deficiency is mainly seen in vitamin K deficiency, severe liver disease, hyperfibrinolysis, DIC, oral anticoagulants, etc.; shortening is seen in hypercoagulable state and thrombotic diseases, etc.

FIB: mainly reflects the content of fibrinogen. Increased levels are seen in acute myocardial infarction; decreased levels are seen in the consumption hypocoagulable lytic phase of DIC, primary fibrinolysis, severe hepatitis, and cirrhosis.

TT: mainly reflects the time it takes for fibrinogen to convert into fibrin. Increased levels are seen in the hyperfibrinolysis phase of DIC, hypo(a)fibrinogenemia, dyshemoglobinemia, and increased fibrinogen degradation products (FDPs) in the blood; decreased levels have no clinical significance.

Normal value

Coagulation factor assay

1Activated partial thromboplastin time (APTT): seconds: 25-37, abnormalities of more than 10 seconds need to be compared with normal controls

2 Prothrombin time (PT): seconds: 11-14, must be abnormal by more than 3 seconds compared with the normal control. Activity: 80-120% INR: 0.8-1.2

3 Fibrinogen (FIB): 2-4 g/L

Fibrinolysis testing

4. Thrombin time (TT): seconds: 12-16. Abnormality should be more than 3 seconds compared with normal control.