What is high myoglobin?

Myoglobin is a very important protein in the human body, and its main function is to store and distribute oxygen. The value of myoglobin represents important significance. The occurrence of many diseases will cause increased myoglobin, such as early acute myocardial infarction, acute muscle injury, etc. There are many possible reasons and the situation is relatively complicated. If your myoglobin level is high, you must first figure out the cause so that you can better deal with it. So, what is the cause of high myoglobin?

A concept

Serum myoglobin (Mb) is one of the earliest markers to increase in patients with acute myocardial infarction (AMI). The blood concentration can increase within 2-4 hours, and Mb is elevated in almost all AMI patients within 6-10 hours. Therefore, Mb positivity is particularly helpful in the diagnosis of early AMI. The condition can return to normal within 24 hours of onset, so Mb negativity is particularly helpful in excluding the possibility of infarction expansion during the course of AMI. The immunoturbidimetric method can complete the determination within 10 minutes.

Two normal values

(1) ELISA method: 3.5-22.8 ng/ml.

(2) RIA method: Serum of healthy adults: 29±16.3μg/L.

3. Clinical significance

(1) The measurement of serum Mb is a sensitive indicator for the early diagnosis of acute myocardial infarction. When blood is drawn 12 hours after the onset of chest pain, serum Mb will increase, while CK and AST are normal. The disease peaks within 24 hours.

(2) The increase in serum Mb in patients undergoing cardiac surgery can be used as an important objective indicator to determine the degree of myocardial injury and healing status.

(3) In clinical myopathy studies, it was found that the serum Mb level in patients with pseudohypertrophic muscular dystrophy was elevated, reaching a maximum of 1150 μg/L.

(4) Acute or chronic renal insufficiency, severe congestive heart failure, etc. also increase.

Four points to note

Strenuous exercise, intramuscular injection, muscle trauma, cardiac catheterization, etc. It can also increase myoglobin.

Five related symptoms

Non-pitting edema of the limbs, severe pseudohypertrophic dystrophy.

6 Related diseases

Glycogen storage disease type V, glycogen storage disease type V in children, muscular dystrophy, viral myocarditis, polymyositis-dermatomyositis, polymyositis, progressive muscular dystrophy.

After reading the above content, you will have some understanding of the high myoglobin. Take a close look at the above content. Cardiomyopathy patients are mostly those with heart problems or the elderly. So in order to prevent your parents from getting this disease in the future, you should read more about it. It may be helpful to you in the future. Come on. Care about the health of the elderly, care about your heart, stay away from various diseases, stay away from unsafe factors, learn to protect yourself, protect your family, and prevent diseases.