Thymopentin Instructions

Many people are not quite clear about what thymopentin is. In fact, such drugs cannot be seen in daily life. They are generally only available in some medical fields. This drug can mainly inhibit many malignant tumors and is more suitable for treating patients who are undergoing radiotherapy and chemotherapy.

The drug ingredient thymopentin is composed of five amino acids: arginine, lysine, aspartic acid, valine, and tyrosine. Its chemical name is N-[N-[N-[NL-arginyl-L-lysyl]-L-α-aspartyl]-L-valyl]-L-tyrosine. Molecular formula: C30H49N9O9. Molecular weight: 679.77.

Drug Effects One of the effects of thymopentin is to induce T cell differentiation. It can selectively induce the conversion of Thy-1- prothymocytes into Thy-1+ T cells. Its T cell differentiation effect is mediated by increased intracellular cAMP levels. Another basic function of thymopentin is to bind to the specific receptors of mature peripheral blood T cells, increase the intracellular cAMP level, and thus induce a series of intracellular reactions, which is also the basis of its immunoregulatory function. Under normal conditions, thymopentin exhibits an immunostimulatory effect, can significantly increase the E-rosette formation rate and conversion rate of splenic lymphocytes, has an enhancing effect on different stages of the primary or secondary immune response, and can increase the number of IgM and IgG or IgA antibody-forming cells. Thymopentin can also enhance the phagocytic function of macrophages, increase the enzyme and phagocytic function of polymorphonuclear neutrophils, increase the content of circulating antibodies, and enhance the immune function of red blood cells. Thymopentin can activate CD4 and CD8 positive cells, maintain the life span of specific Tc cells for a longer time, and can also activate Th cells and induce the function of Ts cells. The anti-infection and therapeutic effects of thymopentin are related to its enhancement of TC cell activity. In anti-infection immunity, an appropriate amount of thymopentin can significantly increase the production of interferon. Induce and promote T cell differentiation and maturation; regulate the ratio of T lymphocyte subsets to make CD4/CD8 tend to normal; enhance the phagocytic function of macrophages; enhance the immune function of red blood cells; improve the activity of natural killer cells; increase the production level of interleukin-2 and the expression level of receptors; enhance the production of gamma interferon in peripheral blood monocytes; enhance the activity of SOD in serum.

It can be used for patients with malignant tumors and immune damage after radiotherapy and chemotherapy; the treatment of hepatitis B; major surgical operations and serious infections; autoimmune diseases such as rheumatoid arthritis and lupus erythematosus; type 2 diabetes and menopausal syndrome; and the elderly with weakened immune function.

Indications (1) For use in patients with chronic hepatitis B aged 18 years and above.

(2) Various primary or secondary T cell deficiency diseases (such as congenital immunodeficiency diseases in children).

(3) Certain autoimmune diseases (such as rheumatoid arthritis and systemic lupus erythematosus).

(4) Various diseases caused by impaired cellular immunity.

(5) Adjuvant treatment of tumors.

Dosage and Administration: Intramuscular injection or intravenous drip in glucose, 1 mg each time, once a day or every other day, generally 15 days as a course of treatment, or the course of treatment is determined according to the condition. There is also a 10mg specification, and the course of treatment is subject to doctor's advice.

Side effects (1) Some patients may experience nausea, fever, dizziness, chest tightness, weakness, etc. A few patients may experience drowsiness.

(2) When used by patients with chronic hepatitis B, ALT levels may rise temporarily. If there are no signs of liver failure, this product can continue to be used.

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