What is the pharmacology of fennel injection?

Xiangene injection is a drug for treating cancer and tumors. It is rarely used alone, but is used together with radiotherapy and chemotherapy. It can better increase the effects of radiotherapy and chemotherapy, minimize the side effects of chemotherapy, and minimize the patient's symptoms and pain. It is suitable for the treatment of various cancers, mainly the treatment of cancers in the abdominal and thoracic cavity. So, what is the pharmacology of Xiangene injection?

The main ingredients of elemene injection are a mixture of β-, γ-, and σ-elemene, and the excipients are soybean lecithin, cholesterol, ethanol, disodium hydrogen phosphate, and sodium dihydrogen phosphate. Properties: This product is a milky white uniform emulsion. Indications: This product combined with conventional radiotherapy and chemotherapy can enhance the efficacy and reduce the toxic side effects of radiotherapy and chemotherapy for malignant tumors such as lung cancer, liver cancer, esophageal cancer, nasopharyngeal cancer, brain tumors, and bone metastasis. It can also be used for interventional, intracavitary chemotherapy and the treatment of cancerous pleural effusion and ascites. Specification: 20ml: 0.1g Dosage and Administration: Intravenous injection: 0.4-0.6g at a time, once a day, 2-3 weeks as a course of treatment. For the treatment of malignant pleural effusion and ascites: generally 200mg-400mg/m2, after drainage of pleural effusion and ascites, inject into the pleural or abdominal cavity, 1-2 times a week or as directed by the doctor.

Adverse Reactions: Some patients may experience phlebitis, fever, local pain, allergic reactions, and mild gastrointestinal reactions after taking the drug. It is contraindicated for use in patients with high fever or pleural effusion and ascites complicated with infection. Notes 1. This product should be used with caution in patients with thrombocytopenia or progressive bleeding tendency; 2. Some patients may have a slight fever after the first use of the drug, usually below 38°C. Taking oral prednisone or antipyretic analgesics 30 minutes before administration can prevent or relieve the fever; 3. This product may cause pain in a small number of patients when injected intracavitary. Before use, local anesthetics should be used according to the patient's specific situation to reduce or relieve the pain so that the patient can tolerate it.

Pharmacology and Toxicology: Elemene is an effective anti-cancer ingredient extracted from Curcuma aromatica of the ginger family. Its main biological activity is to reduce the mitotic ability of tumor cells, induce tumor cell apoptosis, and inhibit the growth of tumor cells. Pharmacological experiments have shown that intraperitoneal injection of elemene emulsion has a significant inhibitory effect on the synthesis of DNA, RNA and protein in tumor cells. The drug can also directly act on the cell membrane to rupture tumor cells, change and enhance the immunogenicity of tumor cells, and induce and promote the body's immune response to tumor cells. This product has minor toxic and side effects and has little impact on normal cells and surrounding white blood cells. The intravenous LD50 is (270.07±18.93) mg/kg, and the oral LD50 is greater than 5 g/kg. Commonly used doses have no teratogenic or mutagenic effects on mice.

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