Fish scale-like skin on feet

Everyone wants to have smooth skin on their face and body. However, it is not easy to have smooth skin. Many people have various skin problems. For example, some people may find that the skin on their feet is like fish scales. Such skin will make people feel very unacceptable because such skin is indeed very ugly. Why does the skin on my feet look like fish scales?

Ichthyosis is a group of hereditary keratotic skin diseases characterized by dry skin. Accompanied by scaly desquamation. The disease usually occurs in children, and the main symptoms are dry and rough skin on the extensor side of the limbs or trunk, accompanied by diamond-shaped or polygonal scales, which look like fish scales or snake skin. It worsens in cold and dry seasons and improves in warm and humid seasons. Prone to relapse. Multi-lineage genetic factors cause abnormal proliferation and differentiation of epidermal cells, leading to increased cell proliferation and/or decreased cell shedding.

Causes 1. Ichthyosis vulgaris is an autosomal dominant genetic disease with incomplete penetrance. It is currently believed that this is caused by mRNA instability and defects in post-transcriptional control mechanisms. 2. Sex-linked recessive ichthyosis is an X-chromosome-linked recessive inheritance. The absence or mutation of the steroid sulfatase gene (STS) causes the accumulation of cholesterol sulfate, which causes the stratum corneum cells to be tightly bound and unable to fall off normally, resulting in the formation of scales. 3. Lamellar ichthyosis is inherited in an autosomal recessive manner. The gene is located at multiple sites, including 2q33-35, 19p12-q12, and 14q11. The TGM1 gene undergoes mutation, deletion, or insertion, resulting in defects in cell adhesion and cell envelope protein cross-linking. 4. Epidermolytic hyperkeratotic ichthyosis is an autosomal dominant genetic disease. The pathogenic genes are related to mutations in the keratin 1 (K1) and keratin 10 (K10) genes, which lead to defects in the synthesis or degradation of keratin, affecting the normal arrangement and function of tension filaments in basal keratinocytes, and thus causing abnormal keratinization and epidermal loosening. 5. Congenital non-bullous ichthyosis-like erythroderma is an autosomal recessive inheritance caused by mutations in multiple genes such as the lipoxygenase 12 (R) (ALOX12B) gene and the lipoxygenase 3 (ALOXE3) gene. 6. Tortugastric linear ichthyosis is an autosomal recessive genetic disease caused by mutations in the serine protease inhibitor Kazal type 5 (SPINK5) gene on chromosome 5p32.

Treatment is mainly symptomatic, with topical moisturizers to keep the skin moisturized. Some patients can take vitamin A or retinoic acid drugs orally. Topical glucocorticoid ointment or tretinoin ointment.

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