What will happen to Baidian Crazy?

Vitiligo is a disease that occurs on the surface of the human body. The clinical manifestations of this disease are relatively obvious on the surface of our skin, and it also causes many consequences. Vitiligo can cause many abnormal conditions, but it can be treated through some treatment methods. Many people may not know the specific symptoms of vitiligo, so what will happen to vitiligo?

Vitiligo is a common acquired localized or generalized skin depigmentation disease. It is caused by the disappearance of melanocyte function in the skin, but the mechanism is still unclear. It can occur in any part of the body, most commonly on the back of the fingers, wrists, forearms, face, neck, and around the genitals. It can also occur in the female vulva, mostly in young women.

There is no significant difference in gender, and the disease can occur in all age groups, but it is more common in adolescents. The skin lesions are depigmented spots, which are often milky white but can also be light pink, with a smooth surface and no rash. The boundaries of the white spots are clear, the pigmentation of the edges is increased compared to normal skin, and the hair inside the white spots is normal or whitened. The lesions often occur in areas exposed to sunlight and damaged by friction, and are often distributed symmetrically. White spots are often distributed according to nerve segments and arranged in bands. In addition to skin lesions, the mucous membranes of the lips, labia, glans penis and inner foreskin are also often affected.

Most patients have no subjective symptoms, and a small number of patients experience local itching in the affected area before or during the onset of the disease. Vitiligo is often accompanied by other autoimmune diseases, such as diabetes, thyroid disease, adrenal insufficiency, scleroderma, atopic dermatitis, alopecia areata, etc.

complication

It is often complicated by diabetes, pernicious anemia, alopecia areata, atopic dermatitis, thyroid disease, primary adrenal insufficiency, scleroderma, malignant tumors, etc.

treat

1. Hormone therapy (1) Systemic therapy is mainly suitable for patients with generalized progressive vitiligo. Oral or intramuscular injection of hormones can stabilize progressive vitiligo as quickly as possible.

(2) Local treatment: Topical corticosteroids are effective in treating localized vitiligo, but attention should be paid to the adverse reactions caused by long-term use of topical corticosteroids. Commonly used drugs in clinical practice include halometasone ointment, mometasone furoate cream, etc.

2. Phototherapy and photochemotherapy (1) Phototherapy with narrowband ultraviolet (NB-UVB) has a certain effect in treating localized or generalized vitiligo.

(2) Photochemotherapy (PUVA) is a good treatment option for localized vitiligo by topical application of furanocoumarins (8-MOP, psoralea corylifolia tincture) + sun exposure. It can be used in adults and children over 5 years old.

3. Transplantation therapy: Suitable for patients in the stable period, with few skin lesions in the past few days and no scarring constitution. Commonly used methods include autologous epidermal transplantation, microskin graft transplantation, autologous cultured melanocyte transplantation, etc.

4. Immunosuppressants: For areas that are not suitable for the use of hormones, or to avoid adverse reactions to long-term use of hormones, topical calcineurin inhibitors (tacrolimus, pimecrolimus) have a certain effect.