Mifepristone side effects

Does everyone know what mifepristone tablets are? This is a very common emergency contraceptive pill that many women should have taken. Some women nowadays do not take any precautions when having sex and will take some emergency contraceptive pills afterwards. Many people think it is very convenient. Generally, taking one pill within 72 hours afterwards can have a good contraceptive effect. Do you know the side effects of mifepristone tablets?

There are two kinds of emergency contraceptive pills now, one is mifepristone tablets, and the other is levonorgestrel tablets. The latter contraceptive requires two tablets to be taken, while the former only requires one tablet. Many people like to take emergency contraceptive pills, but mifepristone tablets also have many side effects.

Mifepristone tablets have side effects? Mifepristone tablets are emergency contraceptive pills that can be taken 2-3 times a year, and should be taken once during a menstrual cycle. Excessive use can affect endocrine function, causing hormone disorders, irregular menstruation, etc. Some early pregnant women experience mild nausea, vomiting, dizziness, fatigue, and lower abdominal pain after taking mifepristone.

Precautions

1. Women taking this product must have had at least one normal menstruation before this cycle and can only use this emergency contraception method during their first unprotected sexual intercourse in this cycle. 2. After taking the medicine, you should not have unprotected sexual intercourse before the start of menstruation in this cycle. If you have sex again, you must use effective contraceptive measures. 3. This product is an emergency contraceptive tablet and does not have an abortion effect. 4. This medicine cannot be used as a regular contraceptive to be taken after each sexual intercourse or monthly, and can only be used as a remedy for contraceptive failure. 5. If this product is used as an emergency contraceptive and contraception fails, it is recommended to terminate the pregnancy.

Pharmacology and Toxicology

Mifepristone is an antiprogestin drug at the receptor level. It has the effects of terminating early pregnancy, preventing implantation, inducing menstruation and promoting cervical ripening. It competes with progesterone for receptors to antagonize the effect of progesterone and also has a certain binding force with glucocorticoid receptors. Mifepristone can significantly increase the sensitivity of the pregnant uterus to prostaglandins. Small doses of mifepristone combined sequentially with prostaglandins can achieve satisfactory results in terminating early pregnancy. Pharmacokinetics: This product is rapidly absorbed after oral administration. The time for semi-synthetic and synthetic mifepristone to reach peak blood concentrations is 1.5-0.81 hours, and the peak blood concentrations are 0.8 mg/L and 2.34 mg/L, respectively, but there are obvious individual differences. It is eliminated slowly from the body, with an elimination half-life of approximately 20-34 hours. 72 hours after taking the medicine, the blood drug level can still be maintained at around 0.2mg/L. This product has a significant first-pass effect, and the level of metabolites in the blood can exceed that of the parent compound 1-2 hours after oral administration.

Pharmacological Action

Mifepristone is an antiprogestin drug at the receptor level. It has the effects of terminating early pregnancy, preventing implantation, inducing menstruation and promoting cervical ripening. It competes with progesterone for receptors to antagonize the effect of progesterone and also has a certain binding force with glucocorticoid receptors. Mifepristone can significantly increase the sensitivity of the pregnant uterus to prostaglandins. The sequential combination of high-dose mifepristone and prostaglandins can achieve satisfactory results in terminating early pregnancy.

Nowadays, many women are irresponsible for their own bodies. During sexual life, they only pay attention to the momentary passion and completely ignore the consequences. Most people should take some measures afterwards, such as taking some emergency contraceptive pills. Mifepristone tablets are a common one. However, everyone must not ignore the side effects of mifepristone tablets. Taking them frequently will cause great harm to the body.