Keratosis pilaris

Many people may not have heard of keratosis pilaris because it is not very common in life and is a hereditary disease. The biggest symptom of keratosis pilaris is on the skin, where some small red rashes will appear. If you feel that there is something abnormal in your body in your life, you should go to a regular hospital for examination and treatment in time.

Keratosis pilaris can cause great damage to the skin because this disease causes some oily substances to appear in the hair follicles of the skin, which can damage the cells in the skin, thus causing certain harm to the skin. If you are interested, you can read on.

Causes

This disease is an inherited skin disease caused by abnormal keratinization process due to autosomal dominant inheritance. Some people believe that vitamin A metabolism disorders and sunlight exposure are important pathogenic factors.

Clinical manifestations

The disease usually begins between the ages of 20 and 30. The condition worsens in summer and patients are sensitive to heat. Typical sites are areas of sebum secretion, such as the face, forehead, scalp, chest and back, where small, firm, normal-skinned papules appear. Gradually, greasy, gray-brown, and black scabs cover the concave surface of the top of the papules. The papules gradually increase in size and become wart-like and merge to form irregular plaques. The proliferation of lesions caused by sweating and friction in the flexor axilla, gluteal groove and pubic region is particularly obvious, forming papilloma-like and proliferative lesions with a foul odor, covered with cracks, maceration and purulent exudate. This disease may cause palmoplantar keratosis, excessive subungual keratosis of the nails, brittle and fragmented nails, etc. In addition, the oropharyngeal, esophageal, laryngeal, and anorectal mucosa may be affected.

examine

The characteristic pathological changes of this disease are: special morphology of dyskeratosis, forming round bodies and grains; loosening of the suprabasal spinous layer, forming suprabasal fissures and crypts; papillae covered with a single layer of basal cells, irregularly proliferating upward into the crypts and fissures; there may be papillomatous hyperplasia, acanthosis and hyperkeratosis, and chronic inflammatory infiltration of the dermis.

diagnosis

The diagnosis is based on clinical manifestations and histopathology.

treat

Patients should avoid exposure to the sun. Patients with mild symptoms do not require treatment and can also use lubricants and retinoic acid preparations topically. Severe cases can be treated with systemic retinoic acid. Marriage between close relatives is prohibited.

The above is some knowledge about keratosis pilaris. I hope you will have a better understanding of this disease after reading it. When facing some hereditary diseases, don’t think that the disease is terrible. As long as you take some treatment measures, the damage to the body can be reduced a lot.