Allopurinol Tablets

Everyone knows that medicine is three-part poison. Taking too much medicine is not good for the body. If taken indiscriminately, it may bring adverse effects to the body. When taking medicine, you must use it under the guidance of a doctor or refer to the instructions for use. Children must be accompanied by an adult to use it. When using it, you should also pay attention to certain precautions, under what circumstances you can't eat it, and under what circumstances you can eat it.

I don't know if you are familiar with the drug Allopurinol Tablets. It would seem too professional to say this. Allopurinol tablets, also known as allopurinol, are a good drug for treating gout-like diseases and the only drug that can control excessive uric acid. So what are its precautions and importance? You can refer to the following content.

Precautions

1. Some patients may experience rash (3%-10%), diarrhea and abdominal pain (1%-3%), low-grade fever, transient elevation of transaminase or neutropenia. The condition can usually be cured by stopping the medication and giving appropriate treatment.

2. This product may cause gout in the initial stage of use, so it can be used together with a small dose of colchicine in the first 4-8 weeks.

3. Drink plenty of water while taking the medicine and make the urine neutral or alkaline to facilitate the excretion of uric acid.

4. When used in combination with azathioprine or 6-mercaptopurine (6-MP), the latter's catabolism may be slowed down and its toxicity increased. The dosage of azathioprine or 6-MP should be reduced to about 1/4 of the usual dosage.

5. It should not be taken together with calcium chloride, vitamin C, potassium phosphate (or sodium), because it may increase the formation of xanthine stones in the kidneys. Avoid using it with bumetanide, furosemide, mecamylamine and pyrazinamide because it may increase the concentration of uric acid in the blood.

6. Patients with poor renal function may accumulate alloxanthine in the body, increasing the adverse reactions of this drug.

7. It may cause allergic liver necrosis, hepatic granuloma formation accompanied by cholecystitis, pericholangitis, exfoliative dermatitis, etc., which are common 3-4 weeks after taking the medicine and should be paid attention to.

8. Use with caution in patients with impaired liver function and the elderly.

9. When used with anticoagulants such as dicoumarol and indandione derivatives, the anticoagulant effect of the latter is increased, and the dosage should be adjusted to prevent bleeding.

10. This product is a liver drug enzyme inhibitor. When used in combination with theophylline, the latter's clearance rate is reduced and the blood drug concentration is increased. The dosage should be adjusted to prevent theophylline poisoning.

Related diseases

Gouty arthritis Hyperuricemia Nephropathy Gout

Pharmacology and Toxicology

This product and its metabolites can inhibit xanthine oxidase, so that hypoxanthine and xanthine cannot be converted into uric acid, that is, uric acid synthesis is reduced, thereby reducing the concentration of uric acid in the blood and reducing the deposition of urate in bones, joints and kidneys. It is the only drug that can inhibit uric acid synthesis. This product can inhibit the activity of liver enzymes. After oral administration, it is completely absorbed from the gastrointestinal tract and metabolized by the liver, with about 70% metabolized into active oxypurinol, neither of which is protein-bound. The blood concentration of this product reaches its peak 2-6 hours after oral administration, and the t1/2 is 1-3 hours. The t1/2 of oxypurinol is 18-30 hours, and it is significantly better in patients with impaired renal function. This product is excreted by the kidneys, 70% as metabolites and 10% in its original form or oxidized in the body to form isoxanthines that are easily soluble in water. Generally, blood uric acid concentration begins to decrease 24 hours after oral administration of this product, and the decrease is most obvious in 2-4 weeks.

Every medicine has its own unique medicinal properties and toxicity. Don't think that a medicine is a good thing just because it can be used to treat a disease. Sometimes doctors will usually advise you not to take medicine for a minor cold. It is best if you can get over it on your own. Medicines have certain side effects on the body, so you should try not to take them unless it is absolutely necessary.