​The efficacy and function of Chinese herbal medicine Jiaogulan

Traditional Chinese medicine is the first choice for many people to treat diseases. Traditional Chinese medicine has a very good effect in treating diseases. However, the use of traditional Chinese medicine cannot be carried out casually, otherwise it will have no effect on the treatment of the disease. The common method of using traditional Chinese medicine is to boil it. This method is simple. At the same time, it is boiled into soup and then drunk. It has a very good effect on the treatment of diseases. The Chinese herbal medicine Gynostemma pentaphyllum is not familiar to many people. What are its effects and functions?

Chinese herbal medicine Jiaogulan effect and function:

The efficacy of Chinese medicine Gynostemma pentaphyllum

Strengthens the spleen and kidneys, resolves phlegm and relieves cough, clears away heat and detoxifies. It is mainly used to treat physical weakness, consumptive spermatorrhea, epigastric pain, diarrhea, cough with excessive sputum, jaundice, frequent urination, cancer, tinea pedis, and axillary odor.

"National Collection of Chinese Herbal Medicines": "Mainly used to treat chronic bronchitis, infectious hepatitis, pyelitis, and gastroenteritis."

The effects of the traditional Chinese medicine Gynostemma pentaphyllum (pharmacological effects)

1. Impact on the immune system

① Effect on nonspecific immunity: Gynostemma pentaphyllum can increase the weight of spleen and thymus of normal mice, improve the phagocytic ability of peritoneal M and the weight of spleen and adrenal gland of young mice, and counteract the decrease in spleen and thymus weight and granulocytopenia caused by cyclophosphamide in mice. Gynostemma pentaphyllum extract can enhance the phagocytic function of peritoneal M in mice and significantly increase the clearance rate of colloidal carbon particles in the blood of mice. Gynostemma pentaphyllum total saponins (GPs) can significantly increase the volume of mouse alveolar M, significantly enhance the phagocytic digestion ability, increase the number of peripheral leukocytes in normal mice and enhance their phagocytic function, and reverse the decrease in the number of leukocytes and the decrease in phagocytic luminescence value caused by injection of prednisone acetate in mice.

②Effect on cellular immune function: Oral administration of Gynostemma pentaphyllum decoction to mice can significantly counteract exudative inflammation and enhance T cell-mediated DTH response. When rats were fed with Gynostemma pentaphyllum extract, the number of T lymphocytes increased significantly. GPs has a certain effect on the transformation of mouse spleen lymphocytes and the activity of DNA polymerase II in vitro. Small doses promote both and promote lymphocyte DNA synthesis, while large doses have the opposite effect. Intraperitoneal injection of GPs in rats significantly enhanced the proliferation response of spleen cells induced by mitogen ConA, decreased the NA content in the hypothalamus and spleen, and decreased the plasma corticosterone level. GPs can significantly counteract the decreased E-rosette formation rate and myocardial transplant rejection in mice induced by cyclophosphamide.

③Effect on humoral immune function: Gynostemma pentaphyllum decoction and GPs have significant effects on humoral immunity. The former can increase the content of mouse specific antibody hemolysin. Oral administration of GPs can significantly increase the level of serum immunoglobulin IgG in mice, and total glycoside II can significantly increase the levels of IgO and IgM. Subcutaneous injection of GPs can increase the LPS-induced splenic B lymphocyte proliferation response in normal mice and cyclophosphamide-induced immunocompromised mice.

④Effect on immune cytokines: GPs can cooperate with ConA to significantly increase the IL-2 activity produced by spleen cells of normal mice and rhubarb spleen deficiency mice. GPs can promote NK cell activity at low doses, but inhibit the activity of NK cells at high doses. Oral administration of GPs can significantly counteract the inhibitory effect of cyclophosphamide on NK cell activity. ⑤ Bidirectional immune regulation: GPs has a bidirectional immune regulation effect on normal mice. A small dose can cause a decrease in spleen weight and active E-rosette formation rate above the median, and an increase below the median; a large dose can cause a decrease in spleen weight and hemolysin level above the median, and an increase below the median.

2. Effects on the cardiovascular system

①Effect on the heart: The aqueous extract of Gynostemma pentaphyllum can increase the coronary flow of the isolated rabbit heart, inhibit the heart, reduce the contraction amplitude, and slow the heart rate. Intraperitoneal injection of GPs and diazepam into mice can prevent lidocaine toxicity and reduce its mortality. GPs can significantly prolong the functional refractory period of isolated guinea pig atria and reduce the automaticity of isolated guinea pig right atria in a concentration-dependent manner. There was no significant effect on the contractility of the atrial muscle. GPs has a protective effect on xanthine-xanthine oxidase (X-XOD)-induced oxygen free radical damage in guinea pig myocardium, delaying the peak of papillary muscle contraction and inhibiting its negative inotropic effect. At the same time, it reverses the changes in the refractory period, excitability and autonomy of the papillary muscles caused by X-XOD and reduces the MDA content in the myocardium. GPs also have a protective effect on the heart damaged by oxygen radicals produced by electrolysis, can reduce the incidence of ventricular fibrillation, inhibit the increase in coronary pressure and weakening of myocardial contractility after electrolytic damage, and inhibit the decrease of SOD in myocardial tissue. GPs has a protective effect on experimental myocardial infarction and myocardial ischemia-reperfusion injury. Intraperitoneal injection can reduce the scope of myocardial infarction in rabbits in vivo, inhibit the increase of serum free fatty acids after myocardial infarction, reduce the MDA content in rat myocardium, protect myocardial SOD activity, and inhibit the increase of CPK and LDH in serum. Intravenous injection of GPs in the early stage of ischemia can significantly reduce the degree of damage to myocardial tissue structure. Intravenous injection of GPs can significantly increase the activity of GSH-Px in myocardial tissue, increase the ratio of GSH-Px to MDA, improve myocardial ultrastructural damage, and maintain the fluidity of myocardial cell mitochondrial membrane in a normal state. For cultured rat cardiomyocytes, GPs can significantly reduce the activities of creatine phosphokinase and LDH in glucose-deficient and oxygen-deficient culture medium and inhibit the release of enzymes. GPs can significantly reduce the incidence of irreversible ventricular fibrillation caused by ischemia-reperfusion in isolated rat hearts. GPs can not only counteract the decrease in vasodilation caused by X-XOD, but also counteract the decrease in vasodilation caused by the inhibition of endothelial relaxing factor by methylene blue.

②Effects on blood vessels and blood pressure: Low doses of Gynostemma pentaphyllum aqueous extract can relax isolated rabbit aortic strips, while high doses can contract them. Intravenous administration can dilate peripheral blood vessels and increase cerebral blood flow in dogs. GPs has a protective effect on the aortic diastolic function of rabbits damaged by xanthine oxidase and methylene blue free radicals. Intravenous injection of GPs showed a significant hypotensive effect in anesthetized cats in a dose-dependent manner. The effect of intravenous injection of GPs on blood pressure in open-chest anesthetized dogs varies with dose. Small doses significantly increase blood pressure, while large doses significantly decrease it. GPs have an inhibitory effect on hypoxic pulmonary vasoconstriction in normal humans (oral administration) and anesthetized dogs (intravenous injection), reducing pulmonary artery pressure, platelet activation, and the levels of angiotensin I and II in plasma, and reversing the decrease in cardiac output during hypoxia. ③Lipid-lowering effect: Jiaogulan Granules can significantly reduce serum TC and TG in patients with hyperlipidemia, increase HDL, and increase the HDL/LDC ratio. Gynostemma pentaphyllum extract promotes the metabolism of TC and β-lipoprotein in rats, and serum and liver TC and TG decrease significantly. Long-term use can accelerate lipid metabolism. Gynostemma pentaphyllum can inhibit or alleviate the formation of AS in rabbits. GPs can prevent the development of hyperlipidemia in rats. For high-fat mice and rats, GPs can significantly reduce serum TC, LDL and VLDL levels, and increase HDL and the ratio of HDL/LDL. GPs can reduce the release of free fatty acids from adipocytes cultured in vitro, and reduce the absorption of glucose and the synthesis of neutral fat by adipocytes.

After understanding the effects and functions of the Chinese herbal medicine Gynostemma pentaphyllum, you should choose it according to your own needs. However, it should be noted that if you feel unwell during the use of the Chinese herbal medicine Gynostemma pentaphyllum, you should stop using it immediately. If the discomfort persists, you should go to the hospital for examination, so that you can have a good grasp of your own condition.