What is lupus disease

No matter who you are, you should pay attention to scientific understanding and symptomatic treatment of lupus, because it is an autoimmune connective tissue disease that seriously threatens people's health. Genetic factors or other environmental factors may cause these diseases.

1. Genetic factors

The onset of systemic lupus erythematosus tends to cluster in families, with 0.4% to 0.5% of first- or second-degree relatives of SLE patients suffering from LE or other autoimmune diseases; the rate of SLE in monozygotic twins can be as high as 70% (24% to 69%), while in fraternal twins the rate is 2% to 9%; more than 50 gene loci related to SLE have been found, most of which are HLA II and III genes, such as DR2, DR3, DQA1, DQB1 in the D region of HLA II and C4AQ in the HLA III gene.

2. Sex hormones

This disease is more common in women of childbearing age, and pregnancy can induce or aggravate SLE. But the evidence is insufficient.

3. Environmental factors and others

Ultraviolet radiation can stimulate or aggravate LE, which may be related to its damage to keratinocytes, DNA changes or the release of "hidden antigens" or the expression of new antigens, which causes the body to produce corresponding antibodies, thereby forming immune complexes and causing damage. Drugs such as hydralazine, procaine, methyldopa, isoniazid, penicillin, etc. can induce drug-induced lupus erythematosus. Certain infections (such as streptococci, Epstein-Barr virus, etc.) can also induce or aggravate the disease.