Can kidney function be restored after damage? The key depends on the cause of the disease

Once kidney function is damaged, it will cause various diseases, and active treatment is imperative. Experts say that whether kidney function can be restored after being damaged depends on the cause of the disease. If the treatment measures are appropriate, renal insufficiency can be completely cured.

Can renal insufficiency be restored? Key point 1 Causes of renal insufficiency:

1. The causes of renal insufficiency can be summarized as follows:

1. Kidney diseases: such as acute and chronic glomerulonephritis, pyelonephritis, renal tuberculosis, acute tubular degeneration and necrosis caused by chemical and biological poisons, kidney tumors and congenital kidney diseases.

2. Extra-renal diseases: such as systemic blood circulation disorders (shock, heart failure, hypertension), systemic metabolic disorders (such as diabetes) and urinary tract diseases (urinary stones, tumor compression), etc.

Generally speaking, when kidney disease is in the renal insufficiency stage, if the treatment measures are appropriate, renal insufficiency can be completely cured. However, if the renal insufficiency is caused by tumors and congenital kidney disease (such as polycystic kidney disease, renal cysts), any current medical treatment is helpless. The only way is to control the growth of the cyst and prevent it from recurring, so as to avoid the disease from worsening and affecting the survival of patients with renal insufficiency.

2. Can renal insufficiency be restored? The key point is to see the severity of renal insufficiency and whether effective treatment measures are taken:

Clinically, renal insufficiency is divided into four stages:

1. Compensatory stage of renal insufficiency: creatinine index is between 120umol/L-133umol/L, and the number of renal units decreases by about 20~25%. At this time, the kidney's ability to excrete metabolic products and regulate water, electrolytes and acid-base balance is still good, and blood creatinine and blood urea nitrogen are normal or slightly elevated.

2. Decompensated renal insufficiency (azotemia stage): creatinine index is between 133umol/L-442umol/L, renal units are reduced by 50~70%, renal concentrating function is impaired, nocturia or polyuria, anemia, fatigue, loss of appetite, nausea and mild general discomfort occur. Azotemia and increased blood creatinine and urea nitrogen are common.

3. Renal failure stage: The creatinine index is between 442umol/L and 707umol/L, the renal units are reduced by about 70% to 90%, the renal function is severely damaged, and there are obvious anemia and gastrointestinal symptoms such as nausea, vomiting, and decreased appetite. Serum creatinine and urea nitrogen increased significantly, acidosis, water and sodium retention, low calcium, high phosphorus and high potassium.

4. Uremia stage: The creatinine index is greater than 707umol/L, and the number of renal units is reduced by more than 90%. This stage is the late stage of chronic renal failure, manifested by multiple organ failure throughout the body, such as nausea and vomiting, irritability, increased blood pressure, palpitations, chest tightness, inability to lie flat, difficulty breathing, severe anemia, convulsions, and coma in severe cases. There are often hyperkalemia, hyponatremia, hypocalcemia, and hyperphosphatemia.

3. Can renal insufficiency be recovered? The key point lies in the treatment of renal insufficiency.

Renal insufficiency is a clinical syndrome that occurs in the late stages of various chronic renal diseases. Its main manifestations are persistent decline in renal function, retention of metabolites, disorders of water, electrolyte, acid and base balance, and complications of various systems. The disease is divided into four stages according to the degree of renal function damage: compensated stage, decompensated stage, renal failure stage, and uremia stage. Therefore, clinical improvement can be achieved through active treatment in the early stages. The increase in creatinine in chronic renal insufficiency is due to damage to the kidney's intrinsic cells and renal fibrosis. The normal renal units with filtration function are replaced by fibrous tissue, losing their detoxification function, causing toxins to accumulate in the body and cannot be excreted.

Experts believe that the key to treatment now is to repair damaged kidney intrinsic cells, block the progression of renal fibrosis, and restore kidney function. As long as the repair is in place, creatinine will naturally decrease gradually, achieving the purpose of treatment.