Maximum dosage of Evodia rutaecarpa

The maximum dosage of Evodia rutaecarpa is about 5g, and the effect can be maintained for about 2.5 hours after taking it. Everyone should take the medicine according to the doctor's advice. Evodia rutaecarpa can dissipate heat, relieve pain, and treat liver and stomach deficiency and coldness. It can also relieve symptoms of vomiting and can be used to lower blood pressure. Now let us understand the medicinal value of the medicinal material Evodia rutaecarpa and then make correct use of the value of Evodia rutaecarpa.

It has other names such as Wuyu, tea ladle, lacquer ladle, stinky ladle tree, left-leaf pure ladle, and rice ladle. It is usually divided into several varieties, including large-flowered Evodia rutaecarpa, medium-flowered Evodia rutaecarpa and small-flowered Evodia rutaecarpa. The nearly ripe fruits of Evodia rutaecarpa and its varieties are commonly used in Chinese medicine. It is hot in nature, bitter and cold in flavor, and has the functions of dissipating heat, relieving pain, relieving adverse effects and stopping vomiting. It is used to treat headaches or stomach and wrist pain caused by liver and stomach deficiency and cold, and yin turbidity. The fruit is pentagonal and oblate, with a diameter of 2 to 5 mm. The surface is dark yellow-green to brown, rough, with dot-like protrusions or sunken oil spots. There is a five-pointed star-shaped fissure at the top, and the base still has fruit stalks covered with yellow hairs. Hard and brittle. The aroma is rich and the taste is spicy and bitter.

Analgesic effect. Its analgesic components are evodia rutaecarpine, evodia rutaecarpine, isoevodia rutaecarpine and evodia lactone. Intravenous injection of 10% ethanol extract of Evodia rutaecarpa can increase the body temperature of rabbits and increase the threshold of contracture of the oral muscles caused by electrical stimulation of the rabbit dental pulp. Its effect intensity is equivalent to that of aminopyrine. 5g/kg and 20g/kg of Evodia rutaecarpa decoction can significantly delay the pain response time, which can last for 2.5 hours. Oral administration of Evodia rutaecarpa has an antiemetic effect, and the antiemetic effect can be enhanced when taken with ginger.

Intravenous injection of 0.03-0.24 g/kg of Evodia rutaecarpa alcohol-water extract to anesthetized cats produced a dependent pressor effect and increased the contractility of the diaphragm, but tetraethylamine could not antagonize it. Intraperitoneal injection to conscious rats also caused a pressor effect. Bilateral nephrectomy, phentolamine or propranolol significantly reduced its pressor effect. Experiments have shown that intravenous and oral administration of Evodia rutaecarpa decoction, granules and distillate have significant hypotensive effects in a dose-dependent manner, with a long duration of hypotensive effect, generally up to more than 3 hours, and no significant effect on heart rate during hypotensive treatment. However, intramuscular injection has a very weak hypotensive effect, and it also has a hypotensive effect on experimental renal hypertension dogs and normal rabbits. Licorice decoction can make Evodia rutaecarpa lose its hypotensive effect. Evodia rutaecarpa has no blocking effect on ganglia, but can counteract the pressor response caused by adrenaline, norepinephrine and vasopressin. The effect of Evodia rutaecarpa alcohol water extract on cardiovascular system is produced by stimulating α-receptors and β-receptors.