The efficacy and function of raw Morinda officinalis

Morinda officinalis is a relatively commonly used medicinal material. In traditional Chinese medicine, many doctors use Morinda officinalis to treat various diseases of patients. In summary, Morinda officinalis can achieve the effects of increasing weight, resisting fatigue, improving immune function, affecting accessory organs, and promoting cortisol secretion. Therefore, for people with poor physical constitution, eating some Morinda officinalis in moderation can have a better effect!

1. Increase weight and resist fatigue

Male Kunming mice weighing 16-18g were selected and divided into 4 groups according to their weight. The blank group was gavaged with 20ml/kg of distilled water every day, and the drug-treated group was gavaged with 20ml/kg of Morinda officinalis decoction for 11 consecutive days. Each group took the medicine once before the experiment. Five mice were placed in each swimming test, and they were weighed before the experiment and loaded with 5% of their actual weight. The results showed that Morinda officinalis could significantly increase the body weight of mice and prolong their continuous swimming time.

2. Impact on immune function

The ACTH bioactivity test was performed on underage mice for 4 days. The results showed that oral administration of 65g/(kg, d), 80g/(kg, d) of Morinda officinalis warm infusion and 60g/(kg, d) of Morinda officinalis 50% ethanol extract could cause thymus atrophy in mice (P values ​​were P<0.05, P<0.001, and P<0.001, respectively). Intraperitoneal injection of 10g/(kg, d) of Morinda officinalis warm infusion resulted in significant thymus atrophy in mice (P<0.001). According to the method reported by Qiao Zhisheng, 21-day-old Kunming mice were selected, both male and female, and blood was separated according to body weight. The positive control group was gavaged with 0.6 ml and 0.2% (g/ml) vitamin B4 solution per mouse per day, and the medication groups were given Morinda officinalis decoction for 10 consecutive days. 24 hours after the last dose, the body weight was weighed, blood was taken from the tip of the tail, the number of white blood cells was counted, and the animals were killed. The thymus was separated and weighed. The results also proved that Morinda officinalis has the function of inhibiting thymus atrophy in mice and increasing the number of white blood cells in their blood.

3. Effects on accessory organs

Oral administration of the crude extract of Morinda officinalis to rats or mice for 14-15 consecutive days showed no anabolic effect (indicated by the increase in body weight, levator ani muscle or glomus cavernosum muscle weight, or mouse kidney weight) and no androgenic effect (indicated by the increase in seminal vesicle weight).

4. Promoting the secretion of corticosterone

ICR male mice weighing about 35g were used to measure the amount of corticosterone in the blood according to the Diamondstone method. The water extract of Morinda officinalis (1g/kg) was orally administered. The results showed that the activity of the glucocorticoid enzyme marker liver AIP was significantly increased, and intraperitoneal injection also showed a higher TAT (tyrosine aminotransferase) activity, indicating that the Morinda officinalis extract has the effect of increasing the level of corticosterone in the blood, and its activity may be due to the stimulation of the pituitary-adrenal cortex system.