What are the tyrosine kinase drugs?

Tynib drugs are a relatively common type of drug in life. This type of drug is very important to people’s bodies. It can treat various cancers and has a certain clearing effect on cancer cells. Therefore, its usage rate in various cancers is very high. There are many types of tynib drugs, and it is difficult for people to understand them comprehensively. Let’s take a look at what tynib drugs are there. I hope everyone can understand.

Tytinib anti-tumor drugs are a new type of biological targeted tumor treatment drugs. Currently, the common tytinib anti-tumor drugs on the Chinese market include: gefitinib, imatinib, imatinib mesylate, nilotinib, sunitinib, and lapatinib.

Gefitinib is a highly specific anti-tumor targeted therapeutic drug developed by AstraZeneca in the UK. It is the first molecular targeted drug used to treat non-small cell lung cancer. It works by selectively inhibiting the signal transduction pathway of epidermal growth factor receptor tyrosine kinase (EGFR-TK).

Imatinib is a novel 2-anilinopyrimidine tyrosine kinase inhibitor. It can effectively inhibit the activity of Bcr-abl tyrosine kinase at the cellular level. The latter is the product of abnormal expression of Ph chromosome in chronic myeloid leukemia (CML). Therefore, imatinib can selectively inhibit the proliferation of Ber-abl positive cell line cells and cells of chronic myeloid leukemia patients and induce their apoptosis.

Sunitinib is a multi-target tyrosine kinase inhibitor, including platelet-derived growth factor receptor, vascular endothelial growth factor receptor and various forms of mutation-activated stem cell factor receptor, inhibiting dysregulated expression of tumor cell RTKs and anti-tumor angiogenesis. Metabolism depends on cytochrome P450 enzymes. It is suitable for patients with gastrointestinal stromal tumors that are resistant to imatinib or progress after treatment, or for the treatment of renal cell carcinoma.

The above is an explanation of the types of tyrosine kinase drugs. I hope everyone can understand and choose different drugs for different symptoms.