What diseases are soy sauce-colored urine common in?

Urine is a waste product excreted by the body. The normal color of urine should be colorless or light yellow. If urine of other colors appears, it is very likely that there is something wrong with the body and that it is caused by some disease. When soy sauce-colored urine appears, it will definitely cause people to be very worried, and possible diseases are also the most concerning thing. So, what diseases are commonly associated with soy sauce-colored urine? Let’s take a closer look below.

The main clinical manifestations of malarial nephropathy are hypertension, proteinuria, hematuria and edema. All four types of malaria may be complicated by this disease, but malaria malaria is more common. Patients with acute renal failure caused by malaria may have high fever, profuse sweating, and insufficient water intake, which may lead to a decrease in effective blood volume, followed by increased compensatory sympathetic nerve activity, increased catecholamine secretion, and strong renal vascular contraction, resulting in a significant decrease in renal blood flow, which may cause or aggravate renal insufficiency.

Chronic progressive renal damage caused by malaria, the main clinical manifestation is nephrotic syndrome. Most patients die within 1 year, with a high mortality rate (approximately 13%). It is usually malaria caused by nephrotic syndrome, which is more common in children. Typical renal edema will appear within 3 weeks after the malaria disease is controlled, and may even cause pleural effusion and ascites, accompanied by hepatomegaly, splenomegaly and anemia. After the edema subsides, proteinuria, renal impairment, and hypertension may persist. A few cases develop rapidly progressive renal failure.

1. Diagnosis of Malaria The four types of malaria in humans have many similarities in clinical manifestations, course of disease, response to drugs, etc., but each has certain particularities. Therefore, the diagnosis should clarify the type of malaria in the patient. The key points of clinical diagnosis are:

(1) In most cases, there is chills or aversion to cold for varying lengths of time before the onset of fever.

(2) The body temperature rises rapidly in a short period of time, lasts for several hours, and then drops quickly, followed by varying degrees of sweating. Measure body temperature once every 2 to 4 hours and analyze the temperature curve. You will find that body temperature at night often drops to normal or below normal temperature.

(3) The attacks are regular, with fever and afebrile periods overlapping and occurring with a certain regularity.

(4) During the intervals between attacks, the patient generally feels well except for fatigue, weakness and slight discomfort.

(5) The disease usually occurs around noon and in the afternoon, and rarely occurs at night.

(6) The clinical symptoms become more severe each time, but after multiple attacks, they gradually alleviate and tend to "heal on their own."

(7) There are clinical manifestations of hemolytic anemia, the severity of which is consistent with the number of attacks.

(8) Splenomegaly. The degree of splenomegaly is related to the course of the disease. In some cases, hepatomegaly is also seen.

In infants and young children, patients with malignant malaria, and newly infected patients, the clinical symptoms are often atypical during the first one or two attacks. In addition, some patients with higher immunity have a large number of protozoa in their blood, but their clinical symptoms are not obvious or absent at all, so physical examination and laboratory tests are especially necessary to confirm the diagnosis. If laboratory tests can detect malarial parasites in peripheral blood, the disease can be confirmed.

2. Diagnosis of malarial nephropathy Malaria is complicated by glomerulonephritis, acute renal failure or nephrotic syndrome during the attack. It is generally considered to be an immunopathological phenomenon and a type III hypersensitivity reaction. The kidney disease caused by the acute phase of malaria is a temporary, reversible lesion. Patients may experience hemolytic anemia, jaundice, low back pain, frequent urination, and urgency to urinate. Urine examination may show that the urine is maroon or soy sauce colored. Some patients who have not recovered for a long time may develop nephrotic syndrome. Malaria nephropathy is more common in patients with falciparum malaria and malaria malaria. The diagnosis can be confirmed by combining the diagnosis of clinical malaria with the clinical manifestations of kidney disease and comprehensive analysis of laboratory tests.