Abnormal blood viscosity

When people reach a certain age, many diseases begin to appear. Of course, people have also deeply realized the importance of health, and exercise and fitness have become a trend. However, due to unreasonable diet, more and more diseases are occurring in the body, and high blood pressure, high blood sugar and thick blood have become common "rich diseases" among people today. Especially thick blood can bring a lot of harm to people, so it is necessary to improve the abnormal blood viscosity in time.

Blood viscosity is the abbreviation of blood viscosity and is one of the indicators reflecting blood viscosity. Blood viscosity is the ratio of the shear stress to which blood flows to the shear rate, and is usually measured using a blood viscometer. Blood viscosity is the most important and basic physiological parameter of blood rheology. It can understand the comprehensive influence of many factors on blood viscosity from an overall level.

Once blood viscosity increases, it may indicate that the body is in a pathological state with or without symptoms, namely hyperviscosity or hyperviscosity syndrome. The factors that affect blood viscosity mainly include red blood cell aggregation and deformability, hematocrit, size and shape, the content of cholesterol, triglycerides and fibrinogen in the blood, etc.

Influencing factors

Red blood cell aggregation deformability, hematocrit

Detection Methods

Rotational viscometers, such as cone and plate viscometers.

Clinical significance

Causes of increase

① The cell concentration is too high: the number of cells in the blood increases relatively. For example, the water content in the body of the elderly is relatively reduced, and the water content in the blood also decreases, so the proportion of blood cells will be relatively increased. As the liquid component in the blood decreases and the solid component increases, the viscosity of the blood will naturally increase.

② Increased blood viscosity: In addition to red blood cells, the blood also contains many plasma proteins, such as globulin, fibrinogen, etc. When these large molecular proteins increase in number, they often adhere to red blood cells to form a grid, increasing the resistance to blood flow and causing increased blood viscosity.

③ Increased aggregation of blood cells: The cells in the blood should perform functions individually rather than aggregate together. When there is some abnormality in the structure of red blood cells or platelets, the red blood cells and platelets will accumulate together, blocking blood vessels and forming blood clots.

④ The deformability of blood cells is weakened: The capillaries in the human body are very thin, and the smallest blood vessel can only allow one blood cell to pass through. Moreover, blood cells have to change their shape when passing through small blood vessels to facilitate passage. When the deformability of blood cells is weakened, it is difficult for them to pass through small blood vessels, affecting the blood flow rate and thus increasing blood viscosity.

⑤ Abnormal blood lipids: Since blood circulates throughout the body, when the lipid content in the blood is too high, the blood's own viscosity can change. In addition, increased blood lipids can inhibit fibrinolysis and further increase blood viscosity. Increased blood viscosity is conducive to the occurrence of coronary heart disease and may even induce acute myocardial infarction.

Reasons for reduction

Various types of anemia, such as iron deficiency anemia, aplastic anemia, etc.

evaluate

Since whole blood viscosity is affected by instrument-detected shear rate, temperature, hematocrit, red blood cell deformability, red blood cell aggregation and plasma macromolecular proteins (fibrinogen, immunoglobulins), etc., a comprehensive analysis of various factors and comprehensive clinical judgment should be made when whole blood viscosity is abnormal, especially the reference range and the gender, age, region and other factors of the selected reference population. Each laboratory should establish reference intervals specific to its measurement system.