Chronic myeloid leukopenia

I don’t know if you have heard of chronic myeloid thrombocytopenia. It is a relatively common blood disease, but modern medical research has not fully identified the cause of it. Leukemia should be a blood disease that everyone is familiar with. After suffering from leukemia, the patient's physical torture will be very great, and it will be accompanied by chronic myeloid and low platelet count. Today I will introduce to you some of the medically considered causes of low platelet count and chronic myeloid leukemia.

The cause of CML is still not fully understood. It is a multifactorial disease involving physical, chemical, genetic and other factors.

Cytogenetics It is recognized that patients with CML have specific cytogenetic abnormalities, namely, marker chromosome ph.

GPD isoenzymes. The clonal nature of CML is further confirmed by the study of GPD isozymes. Currently, the main known GPD gene codon is located on the X chromosome. In female somatic cells, only one of the two GPD regulatory genes is active. As a GPD heterozygous female, there should be two cell populations in the body, namely GPDA and B isozymes. The research guidance found that in heterozygous female CML carrying GPD isoenzymes, their granulocytes, monocytes, red blood cells and lymphocytes only had one type A or type B GPD isoenzyme, further suggesting that the pathological changes of CML originate from cell dynamics at the level of pluripotent stem cells.

In CML, the total amount of granulocytes in the body increases significantly, and this increase is not due to the rapid division and proliferation of leukemia cells, nor is it due to maturation disorders. By prolonging the proliferation pool and the time in the blood, the leukemic stem cell pool expands and the normal hematopoietic stem cell pool shrinks, leading to the accumulation of a large number of cells in the spleen. Although the role of the spleen in the pathogenesis of CML has not yet been elucidated, many experimental and clinical observations have shown that the spleen is conducive to the migration, proliferation and blast transformation of leukemia cells.

diagnosis

Clinical manifestations and symptoms

The onset is slow, and there may be no symptoms in the early stages. The earliest conscious symptoms are often fatigue, low fever, sweating or night sweats, weight loss and other manifestations of hypermetabolism. An enlarged spleen may cause a feeling of heaviness or discomfort in the left hypochondrium or upper abdomen, or a feeling of fullness after eating. Because symptoms progress slowly, it is often months after the onset of illness when patients seek medical attention. Less common symptoms include back pain or pain in the limbs, and severe pain in the left upper abdomen or lower left chest due to splenic infarction. In the late stage when thrombocytopenia occurs, the skin and gums are prone to bleeding, and women may have excessive menstruation. Patients with excessive white blood cells may sometimes experience symptoms caused by "blockage" or embolism of white blood cells in blood vessels, such as blurred vision, respiratory distress, and abnormal penile erection. In these cases, the white blood cell count is often much higher than