In fact, the symptoms of a disease like sebaceous membrane inflammation are not so obvious at the beginning, and there is no particularly effective treatment method at present, and there is not even any specific medicine. Therefore, in order to relieve the patient's symptoms during the attack, we can only provide targeted relief, which can temporarily control the progression of the patient's disease. If necessary, some Chinese herbal medicines can be used for treatment. There is no specific treatment for this disease. Fibrinolytic drugs, chloroquine, azathioprine, cyclophosphamide, etc. have certain therapeutic effects. In the acute inflammatory phase or in the presence of high fever, 40-60 mg of glucocorticoid prednisone per day and nonsteroidal anti-inflammatory drugs have significant effects. For symptomatic treatment, hormones can be used to control the acute process of inflammation, but when the body temperature drops and the nodules subside, relapses often occur after stopping the medication. If the patient has other autoimmune diseases, the existing immune diseases should be treated actively and correctly first. Hormones can be used to control acute symptoms, followed by systemic treatment with Chinese medicine and immunomodulators. In view of the fact that this disease is prone to relapse, anti-relapse treatment should also be given during the treatment process. 1. Clinical features: (1) It is more common in young and middle-aged women; (2) It is characterized by repeated attacks and the appearance of subcutaneous nodules in batches. After the nodules disappear, the local skin will develop depressions and pigmentation of varying degrees. (3) Often accompanied by systemic symptoms such as fever, arthralgia and myalgia; (4) When the lesion invades the visceral fat tissue, different symptoms will appear depending on the affected area. If the internal organs are extensively affected, multiple organ failure, massive bleeding or concurrent infection may occur. 2. Pathological diagnosis: Skin nodule biopsy, its histopathological changes are the main basis for diagnosis, it can be divided into three stages: (1) Stage I (acute inflammatory stage): Degeneration and necrosis of intralobular adipose tissue, infiltration of neutrophils, lymphocytes, and histiocytes, and some vasculitic changes. (2) The second stage (phagocytic stage): A large number of macrophages infiltrate the degenerated and necrotic adipose tissue, phagocytize the degenerated adipocytes, and form characteristic "foam cells". (3) The third stage (fibrosis stage): Foam cells are greatly reduced or disappear and are replaced by fibroblasts; the inflammatory response is replaced by fibrous tissue, and finally fibrosis is formed. |
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