What is the cause of high uric acid

High uric acid level is a common disease. At the same time, it is mainly because the urine in the body contains a lot of urea. The uric acid in daily life is mainly excreted at a solubility level. Excessive uric acid in the body forms other types of diseases, such as urinary stones and some gout patients' symptoms. The amount of uric acid produced and discharged in the body is unbalanced, which will lead to the high uric acid level and the disease is mainly caused by the rising choice of ventilation.

Try to choose some natural plants with less toxic side effects, which can reduce the toxic side effects of uric acid. Otherwise, it is easy to cause secondary damage. There are many reasons why you must pay attention to correct treatment or control in daily life.

In patients with hyperuricemia and gout, when given different uric acid loads, the ratio of urate clearance to glomerular filtration rate is lower than that in normal people. The decrease in uric acid secretion may be related to a decrease in glomerular filtration rate, decreased tubular secretion, or tubular reabsorption. Although high uric acid levels are always present in chronic kidney disease, the relationship between uric acid concentration and serum creatinine and blood urea nitrogen is still unclear.

As renal function declines, the amount of uric acid secreted per unit glomerulus increases, but the secretion capacity of the renal tubules remains basically unchanged, the reabsorption capacity of the renal tubules also decreases, and the ability to clear uric acid outside the kidney increases significantly.

1. Inhibition of renal tubular secretion: one of the most important mechanisms. Inhibition of uric acid excretion and/or increased reabsorption due to drugs, intoxication, or endogenous metabolites. This occurs when anion transport systems are inhibited, two important inhibitors of which are lactate and keto acids.

2. Reduced glomerular filtration: It can also increase uric acid levels. One of the mechanisms is reduced filtration rate, which is the main cause of hyperuricemia in renal insufficiency or failure. Increased net uric acid reabsorption can occur in the setting of volume depletion and is one of the mechanisms by which diuretics may induce hyperuricemia.

3. Increased tubular reabsorption: Hyperuricemia can also be caused by enhanced reabsorption distal to the secretion site. These may occur with dehydration or diuretic therapy in patients with diabetes.

Many patients have both increased uric acid production and decreased excretion.

Such as patients with glucose 6-phosphatase deficiency and hereditary lactose intolerance. Alcohol can also cause uric acid retention in two ways. Excessive alcohol intake accelerates the liver's degradation of ATP and increases the production of uric acid. The uric acid caused by alcohol also prevents the excretion of uric acid. Alcoholic beverages high in purines, such as beer, are also a significant factor.

The above are the reasons for high uric acid levels. We must pay attention to the correct treatment or control of the reasons. The ability to clear uric acid outside the kidney is significantly increased, mainly due to the inhibition of tubular secretion and reduced glomerular filtration. The glomerulus reabsorbs a lot of uric acid, so in daily life we ​​must do some aerobic exercise, drink more boiled water and eat some fruits and vegetables.