What is the normal level of estradiol before egg retrieval?

Many people do not know what estradiol is. In fact, it has great clinical significance. Whether estradiol increases or decreases, it may reflect some adverse conditions. If it increases, it is common in female precocious puberty or hormone-secreting tumors.

1. The normal value of female estradiol is 48-521 pmol/L in the preovulatory period, 70-1835 pmol/L in the ovulatory period, and 272-793 pmol/L in the postovulatory period. Generally, the estradiol level is 300 pmol/L per follicle. The more follicles there are, the higher the blood value will be. Conversely, the fewer follicles there are, the lower the blood value will be.

2. Increased height is seen in female precocious puberty, male breast development, pregnancy (especially twins or multiple births), estrogen-secreting tumors, ovulation-inducing drugs (such as chlorpheniramine), male feminization, ovarian tumors, anovulatory uterine bleeding and cirrhosis.

3. Decrease is seen in ovarian tumors, hydatidiform mole, intrauterine fetal death, pregnancy-induced hypertension syndrome, hypothalamic tumors, hypopituitarism, ovarian insufficiency, oophorectomy, delayed puberty, primary and secondary amenorrhea, menopause, oral contraceptives, etc.

4. Pathological causes of increased estradiol values ​​1) Ovarian diseases: Ovarian granulosa cell tumor, ovarian embryonal tumor, ovarian fat cell tumor, sex hormone-producing tumor, etc., all show ovarian hyperfunction and increased estradiol secretion. 2) Heart disease: myocardial infarction, angina pectoris, coronary artery stenosis. 3) Others: systemic lupus erythematosus, liver cirrhosis, and male obesity.

5. Pathological causes of decreased estradiol: 1) Ovarian diseases: ovarian absence or hypoplasia, primary ovarian failure, ovarian cysts. 2) Pituitary amenorrhea or infertility. 3) Others: hypothyroidism or hyperthyroidism, Cushing's syndrome, Addison's disease, malignant tumors, large-scale infections, renal insufficiency, focal lesions of the brain and pituitary gland, etc. can all reduce plasma estradiol.