The best medicine to repair glomeruli

The manifestation of glomerular damage is kidney disease. In general, proteinuria, hematuria and hypertension are manifestations of nephritis. There are many reasons for glomerular damage. The glomerular damage caused by different reasons also causes different degrees of acuteness and slowness. However, during this process, kidney function will gradually decline. Repairing the glomeruli requires finding the root cause of the disease.

The best medicine to repair glomeruli

Creatinine is mainly a metabolite of creatine in the body. Since serum creatinine concentration is affected by the muscle volume in the body, there are large individual differences in serum creatinine levels. For example, young and middle-aged men, athletes, manual laborers, those with well-developed muscles and large muscle mass, or those who eat a lot of lean meat have relatively high serum creatinine concentrations. Serum creatinine is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecule that can be filtered through the glomerulus and is rarely absorbed in the renal tubules. Almost all of the creatinine produced in the body daily is excreted in the urine and is generally not affected by urine volume. After the urine volume recovers, creatinine will also return to normal, which is common in the oliguria stage of acute nephritis. The increase in creatinine caused by chronic nephritis is mostly due to the loss of function of glomerulosclerosis. Taking medicine to lower creatinine by dozens of points will not be of much significance if the inflammation still exists. Glomeruli cannot regenerate, and when one breaks down, one is missing. Completely sclerotic glomeruli have no function of secreting urine. Partially damaged glomeruli can retain some function if immune complexes are no longer deposited. Therefore, the goal of treatment is mainly to interrupt the progression of kidney disease in order to preserve the remaining kidney function and maintain a normal life.

Causes of glomerular damage

The etiology and pathogenesis of glomerular diseases are very complex, and many factors are involved, such as infection, autoimmunity, drugs, genetics, environment, etc. Among them, immune damage is a common link in the occurrence of most glomerular diseases, and almost all glomerular diseases involve immunological mechanisms in most processes.

According to statistics, only 15%-20% of cases are caused by the transformation of acute nephritis. A considerable number of patients with chronic nephritis have an insidious onset and no obvious clinical symptoms at the beginning, but kidney disease progresses slowly and symptoms only appear after infection or fatigue. This type of patients accounts for 50%-70% of chronic nephritis patients, which may be related to long-term, chronic, latent infections such as bacteria and protozoa.

What are the symptoms of glomerular damage?

Signs:

Patients may have anemic appearance, pale lips and nails, edema of the eyelids, face and even lower limbs, and in severe cases, pleural effusion and ascites may occur.

Low back pain:

In mild cases, there is soreness and weakness in the waist, while in severe cases, there is back pain, which worsens after fatigue and is mainly located at the costovertebral angle.

Edema:

Most patients have varying degrees of edema. In mild cases, it only manifests on the face, eyes and loose tissues, while in severe cases, it spreads throughout the body and may also cause pleural effusion and ascites.

Abnormal changes in urine:

It is an inevitable symptom in patients with chronic nephritis.

anemia:

Chronic nephritis may cause mild to moderate anemia, most of which are related to the decrease of erythropoietin in the kidney. In end-stage nephritis, severe anemia occurs.

Renal Insufficiency:

The renal function damage of chronic nephritis is mainly manifested by decreased glomerular filtration rate and creatinine clearance rate. However, since most patients have not dropped below 50% of the normal value when they seek medical treatment, serum creatinine and urea nitrogen are within the normal range, and clinical symptoms of renal insufficiency such as azotemia do not appear.