What to do if platelets don't coagulate

If platelets do not coagulate, there are many reasons for this. If there is a problem with the coagulation factors, it will cause platelets to not coagulate. The most common ones are some blood diseases. Of course, if there is a problem with the liver and gallbladder, it may also cause platelets to not coagulate. Different methods should be adopted according to different situations. Especially when the condition is more serious, you must strengthen care and understand the specific condition.

What to do if platelets don't coagulate

①Implement routine nursing care for hematopoietic system diseases. ②During the acute attack period, you should rest in bed. ③ Provide high-protein, high-vitamin and easily digestible diet, avoid eating hard, fried or irritating foods, so as to avoid the formation of oral blood blisters and even induce gastrointestinal bleeding. When there is gastrointestinal bleeding, the patient should be fasted, or fed liquid or cold liquid food according to the situation. Only when the bleeding condition improves can it be gradually changed to semi-liquid food with less residue, soft rice, normal food, etc. No alcohol. ④ In terms of psychological care, pay attention to keeping the patient calm and avoid excessive emotional tension that may stimulate or aggravate bleeding. Sedatives can be given when necessary. ⑤ Strengthen necessary protection to avoid bleeding caused by trauma. Clothes should be soft and loose to avoid aggravating skin purpura.

Causes

(1) Immune factors: It is now generally recognized that the cause of idiopathic thrombocytopenic purpura is related to immunity, and humoral immunity is considered to be the central link. It has been confirmed that most patients with idiopathic thrombocytopenic purpura have antiplatelet antibodies in their serum, especially PAIgG and PAC3, which fix the Fc fragment of IgG antibody molecules on the surface of platelets and bind to the complement C3b receptor, causing the platelets to be phagocytosed and destroyed, or the antiplatelet antibodies bind to platelet-associated antigens and directly dissolve and destroy the platelets under the action of complement C5~C9. (2) Splenic factors: It has been confirmed that most of the platelets of patients with idiopathic thrombocytopenic purpura rupture in the spleen. After splenectomy, the platelet count can increase rapidly, the bone marrow megakaryocytes return to normal, and the anti-platelet antibodies in the serum of most patients decrease, showing clinical improvement to varying degrees. It shows that the spleen is related to the onset of idiopathic thrombocytopenic purpura. (3) Platelet function is also abnormal. (4) Capillary defects: The capillary fragility of patients with idiopathic thrombocytopenic purpura is increased. However, after the application of glucocorticoids, the bleeding symptoms can be significantly improved without increasing the platelet count, indicating that capillary defects are related to this disease.